main effect:
⒈The effect of regulating blood lipids: giving 0.2g/kg and 1.0g/kg of Perilla Oil to hyperlipidemic mice for 20 consecutive days can reduce their serum total cholesterol (TC) by 13.9% and 29.7% respectively. Fatty oil was administered orally to hyperlipidemia rats at 0.4g/kg and 1.0g/kg for 20 consecutive days, which significantly reduced the rat serum TC and LDL-C (low-density lipoprotein cholesterol) levels and increased high-density lipoprotein cholesterol. Cholesterol (HDL-C)/TC and HDL-C/LDL-C ratio; the effect of reducing serum triacylglycerol (TG) is weak. It has no obvious effect on HDL-C content, but can change the proportion of its subcomponents and increase the HDL2-C/HDL-C and HDL2-C/HDL3-C ratios. Perilla oil can reduce the levels of total cholesterol and triacylglycerol in rat serum; if combined with Mg, the effect will be more rapid. Perilla oil is rich in α-linolenic acid (α-LNA). α-LNA can significantly reduce total plasma cholesterol without causing the accumulation of cholesterol in the liver, while linoleic acid can cause the accumulation of cholesterol in the liver. . Therefore, perilla oil rich in α-LNA is more beneficial to the human body than traditional cooking oil rich in linoleic acid.
⒉ On the tumor suppressive effect, food containing 12% perilla oil was fed to rats treated with N-methyl-N-nitrosourea to induce cancer. A significant decrease in the incidence of colon cancer was observed at 35 weeks. . At 10 weeks, there was no significant change in the content of tumor-promoting bile acids in the feces, but the deoxycholic acid-induced colonic mucosal urinine dehydroxylase activity (a tumor-promoting marker) in the colon was significantly reduced. It can be seen that the role of perilla oil is to reduce the sensitivity of colon mucosa to tumor promoters. Feeding rats with food containing 5.0% perilla oil from weaning to 7 weeks of age can significantly inhibit the lung metastasis of intravenously injected ascites tumor cells and reduce the number of metastases on the lung surface. Perilla oil can also significantly inhibit the incidence of breast cancer caused by the chemical carcinogen 7,12-dimethylbenzanthracene (DMBA) or subcutaneous transplanted tumor strains, reduce tumor weight and volume, and prolong the time for tumor appearance; Colon cancer and kidney tumors have significant inhibitory effects. The tumor-suppressing mechanism of n-3 fatty acids such as A-LNA is not yet clear, but it is believed to be related to the competitive inhibition of n-6 fatty acids by n-3 fatty acids and the reduction of dienoprostaglandin levels in the body.
⒊Anti-thrombotic effect: When 3-week-old male rats are given food containing 10% perilla oil for 5-6 weeks, when the platelet phospholipid eicosapentaenoic acid (EPA)/arachidonic acid is 7.5-10μ/ml, perilla The platelet aggregation effect of rats in the oil group (all or no phenomenon) was significantly lower than that of the safflower oil group, but at a higher concentration (15-20 μg/ml) (measured by turbidimetric method), there was no significant difference between the two groups. Sexual differences. This suggests that it is important to evaluate platelet aggregation below the collagen threshold concentration. The release of 5-hydroxyzylamine from platelets of rats in the perilla oil group was also significantly reduced.
⒋Other effects: Rats were continuously fed with feeds rich in perilla oil and safflower oil for two generations. Compared with the safflower oil group, the leukotriene LTB4 released by the polymorphonuclear leukocytes of the rats in the perilla oil group was the highest. It decreased by 27%, and the activity of allergic slow-reacting substances decreased by 59%, while the amount of LTB5 increased significantly, and the total amount of LTB increased. In addition, perilla oil has an inhibitory effect on the intermediate of excessive reaction (platelet aggregation activating factor), so it is believed that perilla oil has an inhibitory effect on allergic reactions and inflammation. When feeding food containing 5% perilla oil to spontaneously hypertensive rats prone to stroke (SHR-SP) compared with the safflower oil group, the average survival time of male rats was extended by 17% and that of female rats was extended by 15%. . The survival time of female rats in both food groups was 40% longer than that of male rats. The systolic blood pressure of rats in the perilla oil group was significantly lower than that of the normal food and safflower oil groups, and platelet aggregation also decreased.
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